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PHENYL RING-SUBSTITUTED CURCUMIN DERIVATIVE USABLE FOR PREVENTING AND TREATING SENILITY BY HAVING EXCELLENT BLOOD-CEREBRAL PERMEABILITY THAN EXISTING CURCUMIN, AND A USE THEREOF
PHENYL RING-SUBSTITUTED CURCUMIN DERIVATIVE USABLE FOR PREVENTING AND TREATING SENILITY BY HAVING EXCELLENT BLOOD-CEREBRAL PERMEABILITY THAN EXISTING CURCUMIN, AND A USE THEREOF
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机译:苯环取代的姜黄素衍生物,可通过具有比现有姜黄素更高的血脑渗透率来预防和治疗衰老,及其用途
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PURPOSE: A phenyl ring-substituted curcumin derivative is provided to have excellent permeability than existing curcumin, and to have excellent bonding-affinity to B-amyloid(1-42) aggregate.;CONSTITUTION: A phenyl ring-substituted curcumin derivative is in chemical formula 1. In chemical formula 1, R1 and R2 is respectively and independently H, OH, alkyl, haloalkyl, alkyloxy, haloalkyloxy, amino, monoalkylamino or dialkylamino, R3 and R4 is independently and independently H, OH, alkyl, haloalkyl, alkyloxy, haloalkyloxy, amino, monoalkyl amino, dialkylamino, halopolyethyleneoxy, halopolyethyleneamino, 11 C monoalkylamino, 11 C dialkylamino, 123 I iodoalkyloxy, 124 I iodoalkyloxy, 125 I iodoalkyloxy, 131 I iodo alkyloxy, 123 I iodopolyethyleneoxy, 124 I iodopolyethyleneoxy, 125 I iodopolyethyleneoxy, 131 I iodo polyethyleneoxy, 18 F fluoropolyethyleneoxy, 18 F fluoroalkyloxy or 18 F fluoropolyethyleneamino.;COPYRIGHT KIPO 2013
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