pH Composition for preventing improving or treating inflammatory disease comprising sensitive block copolymer comprising curcumin derivative

摘要

The present invention relates to a composition for preventing, improving or treating inflammatory diseases comprising a curcumin derivative-containing pH-sensitive block copolymer as an active ingredient. The pH-sensitive block copolymer containing a curcumin derivative according to the present invention forms micelles to load a large amount of curcumin and allows the curcumin derivative to last longer in the body. In addition, micelles are disrupted at a weakly acidic pH of the inflamed area, and the acetal bond to which the curcumin derivative is linked is broken, so that the curcumin derivative is produced and released, which acts specifically on the inflamed area and has little toxicity to normal cells, so it has an anti-inflammatory effect by itself. .