A novel dopaminergic neuronal DJ-1 knockout cell line for diognostic markers

摘要

the present invention is the discovery of Parkinson's disease pathology genetic markers capable novel DJ -1 (DJ-1 ) mutant cell line loss, the treatment of Parkinson's disease from the pathological marker gene discovered by using this, the prevention and treatment of Parkinson's disease by drug discovery and diagnostic kits, and Parkinson's disease pathology genetic marker that can be used in the clinical diagnosis for the relief of disease progression relates to a method for screening inhibitors. Gene marker according to the invention DJ -1 (DJ-1) loss of function mutation is black quality may decrease if the expression by the cell line may be used to increase and decrease it as a clinical diagnostic marker for the target gene results in the degradation, these targets can be applied to clinical diagnosis of Parkinson's disease, also have customized care as a protective treatment of chronic degenerative brain disease for the treatment, prevention and mitigation navigation symptoms of Parkinson's disease, cell-based assay can be used as a very useful tool . ;