Method for producing alpha-lipoic acid using lipoic acid synthesis associated enzymes

摘要

The present invention relates to a method for producing alpha-lipoic acid using alpha-lipoic acid biosynthesis-related enzymes, and more specifically, to a recombinant lipoic acid synthase and lipoyl trasperase through metabolic redesign. (lipoyl transferase), lipoate protein ligase A (lipoate protein ligase A) relates to a method for producing alpha-lipoic acid by artificially expressing without metabolic regulation of its own genes. In addition, a recombinant strain of pyruvate dehydrotenase complex and Fe-S cluster, which is related to alpha-lipoic acid synthesis, was prepared to effectively increase the biosynthesis of alpha-lipoic acid. It is about.;Alpha-Lipoic Acid, Metabolic Redesign, Biological Production Methods