PROLONGED-RELEASE PHARMACEUTICAL COMPOSITIONS FOR PEPTIDE DELIVERY

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to medicine. What is presented is a liquid polymeric pharmaceutical composition for controlled release of a therapeutic polypeptide containing pharmaceutically acceptable, water-insoluble, a biodegradable polymer, a pharmaceutically acceptable organic solvent and a therapeutic polypeptide conjugated with one or more lipophilic groups and/or with one or more amphiphilic groups. What is presented is a method for preparing said composition involving the stage of dissolving the biodegradable polymer in the pharmaceutically acceptable organic solvent and the stage of mixing the prepared polymer solution with an effective amount of the therapeutic polypeptide.;EFFECT: invention provides producing the pharmaceutical composition showing higher stability in vitro and reduced initial "explosive" release of the therapeutic polypeptide in comparison with the composition wherein the therapeutic polypeptide is not conjugated with the lipophilic and/or amphiphilic groups.;17 cl, 4 dwg, 3 tbl, 14 ex