This application claims priority to US Provisional Application No. 61 / 260,916, filed Nov. 13, 2009, with respect to the prior application of the palonosetron metabolite.

摘要

Provided are metabolites of palonosetron that can be used in treating animals, particularly humans, of the formula (I): or a pharmaceutically acceptable salt or prodrug thereof; wherein R1 and R4 independently can be H, hydroxyl, or carbonyl; and wherein R3 can be Formule (II) or Formule (III).