Manner of nuclear acid sorting in order to choose the donor where the one for intersection adaptation for transfusion reshipiento is registered

摘要

Disclosed are a method and an algorithm for genetic cross-matching based ON the comparison of recipient and donor genotypes-and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing ON phenotype prediction, instead relies ON a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry and to maximize molecular compatibility. The genotypes can be matched based ON the weighted clinical significance of a genotypic difference between donor and recipient and such that certain mismatches are more acceptable than others.