COMPOUND HAVING ACTIVITY SUPPRESSING ACTIVATION OF TGF-β RECEPTOR, METHOD OF SCREENING THE SAME, AND COMPOSITION FOR PREVENTION OR TREATMENT OF DISEASE CAUSED BY HEPATITIS C VIRUS

摘要

An object of the present invention is to provide a compound capable of suppressing activation of TGF-β receptor by HCV, and a screening method thereof, wherein HCV-derived NS3 protease binds to type I TGF-β receptor, It was found that TGF-β receptor is activated by binding. Furthermore, the binding site of NS3 protease and type I TGF-β receptor was identified, and it was also found that activation of TGF-β receptor by NS3 protease is suppressed by an antibody that recognizes these binding sites. Further, the present inventors have found that it is possible to screen for a compound that suppresses the activation of the TGF-β receptor by using, for example, inhibition of binding between NS3 protease and type I TGF-β receptor as an index.