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Pigment epithelium-inducing factor: characterization, genomic organization and sequence of PEDF gene
Pigment epithelium-inducing factor: characterization, genomic organization and sequence of PEDF gene
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机译:色素上皮诱导因子:PEDF基因的表征,基因组组织和序列
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摘要
Nucleic acids encoding the neurotrophic protein known as pigment epithelium-derived factor (PEDF), a truncated version of PEDF referred to as rPEDF, and equivalent proteins, vectors comprising such nucleic acids, host cells into which such vectors have been introduced, recombinant methods for producing PEDF, rPEDF, and equivalent proteins, the rPEDF protein and equivalent proteins of rPEDF and PEDF -BP, -BX and BA, and the PEDF protein produced by recombinant methods. Effects and use of these variants on: 1) neuronal differentiation (neurotrophic effect), 2) neuron survival (neuronotrophic effect), and 3) glial inhibition (gliastatic effect) are described.
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