Intramural Research Program of the National Institutes of Health, National Institute of Environmental Health Sciences (NIEHS)

摘要

Use of sPLA₂ inhibitors (for example, BPPA (5-(4-Benzyloxyphenyl)-4S-(7-phenylheptanoylamino) pentanoic acid)) within about 9 hours after poisoning with a liver toxin, for example, acetaminophen (APAP), was shown to increase survivorship. The inhibition of sPLA₂ lead to markedly decreased progression of liver injury as reflected in lower alanine aminotransferase (ALT—a biomarker for liver injury) levels, and to significantly higher survival rates. Similar treatment in human patients suffering from hepatotoxicity will be effective in increasing survival, and treatment with other sPLA2 inhibitors will also be effective in decreasing liver damage and mortality.