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ACTIVATED MESENCHYMAL STEM CELLS FOR WOUND HEALING AND IMPAIRED TISSUE REGENERATION
ACTIVATED MESENCHYMAL STEM CELLS FOR WOUND HEALING AND IMPAIRED TISSUE REGENERATION
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机译:活化的间充质干细胞用于伤口愈合和组织再生受损
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摘要
Inflammatory cytokines e.g. IFN-γ, serve as initiating stimuli for mesenchymal stem cell (MSC) immunosuppresive activity in vivo. Other inflammatory cytokines, such as TNF alpha, the molecule hemoxygenase I, and TLR ligation of MSC, may also provide such a response. Activated MSC's promote tissue regeneration in conditions such as aging, where regeneration is impaired. Wound healing in aged mammals was enhanced by restoring tensile strength to the levels of younger mammals. Activated MSCs were useful in treating wounds in diabetic primates.
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