A METHOD OF ASSESSING WOUND HEALING POTENCY OF A MESENCHYMAL STEM POPULATION AND RELATED METHODS OF SELECTING MESENCHYMAL STEM CELLS AND IDENTIFYING TISSUE AS STARTING MATERIAL FOR PRODUCING A MESENCHYMAL STEM CELL POPULATION

摘要

The present invention relates to a method of assessing the wound healing potency of a mesenchymal stem cell (MSC) population. In addition, the present invention concerns a method of selecting a MSC for producing a stem cell population under cGMP conditions, a method of selecting a MSC population for producing a stem cell population for subsequent pharmaceutical administration. Further the present invention relates to a method of selecting a MSC population for generating a master cell bank and a method for identifying a tissue suitable as starting material for producing a MSC for pharmaceutical use. Said methods comprise determining in a medium the level of at least two proteins selected from the group consisting of Angiopoietin 1 (Ang-1), Transforming Growth Factor β (TGF-β), Vascular Endothelial Growth Factor (VEGF) and Hepatocyte Growth Factor (HGF) secreted in a medium by the MSC.