Minocycline enhances the mesenchymal stromal/stem cell pro-healing phenotype in triple antimicrobial-loaded #hydrogels for inoculated cutaneous wound healing

摘要

Conclusions: Minocycline induces a favorable change in MSC invasion capacity, proliferation, gene expression, ECM attachment, and VEGF secretion with subsequent increased angiogenesis. MSC, minocycline, vancomycin, and linezolid-loaded hydrogels decrease bacterial bioburden and accelerate healing in bacteria-inoculated wounds, demonstrating potential clinical viability for infection prophylaxis and advanced wound healing for full thickness cutaneous wounds.