METHOD FOR INDUCING AN IMMUNE RESPONSE AGAINST AVIAN, SWINE, SPANISH, H1N1, H5N9 INFLUENZA VIRUSES AND FORMULATIONS THEREOF

摘要

A vaccine for immunization against Type A influenza virus is provided having an immunologically effective amount of peptide constructs obtained by linking together two or more peptides based on or derived from different molecules, and methods for producing the same. The peptide constructs have the formula P₁-x-P₂ or P₂-x-P₁ where P₁ is associated with Type A influenza highly conserved protein such as but not limited to M2e matrix protein, NP1 nucleoprotein, HA2 core 1, and HA2 core 2, where P₂ is a peptide construct causing a Th1 directed immune response by a set or subset of T cells to which the peptide P₁ is attached or that binds to a dendritic cell or T cell receptor causing said set or subset of dendritic cell or T cells to which the peptide P₁ is attached to initiate and complete, an immune response, and x is a direct bond or divalent linker for covalently bonding P₁ and P₂.