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Mutant Δ-5 desaturases mutated in the heme-binding motif (HPGG) and their use in making polyunsaturated fatty acids
Mutant Δ-5 desaturases mutated in the heme-binding motif (HPGG) and their use in making polyunsaturated fatty acids
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机译:血红素结合基序(HPGG)中突变的突变Δ-5去饱和酶及其在制备多不饱和脂肪酸中的用途
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摘要
The present invention relates to mutant Δ5 desaturases, which have the ability to convert dihomo-γ-linolenic acid [DGLA; 20:3 ω-6] to arachidonic acid [ARA; 20:4 ω-6] and/or eicosatetraenoic acid [ETA; 20:4 ω-3] to eicosapentaenoic acid [EPA; 20:5 ω-3] and which possess at least one mutation within the HPGG motif of the cytochome b5-like domain. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding Δ5 desaturases, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”] using these mutant Δ5 desaturases in oleaginous yeast, are disclosed.
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