Desaturase-defective fungal mutants: useful tools for the regulation and overproduction of polyunsaturated fatty acids

摘要

Increasing demand for biologically important polyunsaturated fatty acids has led to the search for alternative sources, especially fungi. Although successes in this area have induced interest in developing fungal fermentation processes, manipulation of their lipid composition requires new biotechnological strategies to achieve high yields of the desired polyunsaturated fatty acids. Fungal desaturase mutants with unique enzyme systems are useful not only for the regulation and overproduction of valuable Polyunsaturated fatty acids but also because they are excellent models for the elucidation of fungal lipogenesis.