Method for reducing itraocular pressure and Method for ensuring the release of a therapeutic composition for reducing intraocular pressure

摘要

METHOD TO REDUCE INTRAOCULAR PRESSURE AND METHOD TO ENSURE THE RELEASE OF A THERAPEUTIC COMPOSITION TO REDUCE INTRAOCULAR PRESSURE. They are provided for reducing intraocular pressure in a subject having an eye disorder causing high intraocular pressure, such as glaucoma. The method comprises administering to the subject an effective amount of an eye pressure lowering pharmaceutical composition comprising an A-3 subtype adenosine receptor antagonist (A 3 AR), including dihydropyrine, pyridine, pyridine or triazoloquinazoline salt, and derivatives of them expressly having an A? 3Ar antagonist activity, including, for example, the nucleoside-based A? 3AR antagonist, MRS-3820. Additionally, a method is provided for ensuring the release of a topically administered therapeutic composition to reduce intraocular pressure, which method expressly requires the physical opening of a channel through the corneal barrier of the patient's eye by a microneedle or micropipette to allow transporting the topical composition to before the eye chamber.