Fusion Proteins With Representation of different allergens: Proposal for Vaccine allergy to dust mites

摘要

The present Invention relates to recombinant DNA molecules encoding peptides FUSED to different allergens of Dermatophagoides pteronyssinus and Blomia tropicalis with potential usefulness in the Prevention and Treatment of allergies caused by House dust mites.Specifically, The Invention describes fusion proteins composed of different Fragments of the allergens der P 1, P 2, P 7 der, der, der p t 8, blo blo blo T 5, 8, 12 and 18 t t, blo blo T 13 reduced reactivity with serum ige in allergic and allergic reactivity comparable IgG in Serum Cos and non allergic.It also describes the methods of production of these Molecules in an expression system based on Eschericia Coli bacteria and purification. The Invention also relates to safe and effective Vaccines.