House dust mite major allergens Der p 1 promote the production of IL-8 and MUC5AC in human airway-derived epithelial cells by NF-kB mechanism

摘要

Backgroud： House dust mite allergens （HDM） is the most commonly encountered patho- gen of humans, predominantly causing bronchoconstriction in asthma patients and inducing an inflammatory response in the lungs dune to the release of cytokines, chemokines and other medi- ators. During the clinical course of treatment, dexamethasone has a limited effect on asthma pa- tients, especially for refractory asthma, because it is infective to block a large number of theneutrophils to invade the lung tissue.