STABILIZATION OF IMMUNOHLOBULINS WITH THE HELP OF WATER COMPOSITION WITH HYSTIDINE AT pH FROM LOW ACID TO NEUTRAL

摘要

The present invention provides, along with other aspects, storage-stable aqueous formulations of immunoglobulins with histidine at a pH ranging from weakly acid to neutral. The present invention also provides methods for stabilizing immunoglobulin compositions by preparing them with histidine at a pH in the range from weakly acid to neutral. Advantageously, the methods and compositions described in this application allow to obtain stable aqueous compositions of immunoglobulins at a pH in the range from weakly acid to neutral, suitable for parenteral administration.