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Use of compositions comprising a beta-2 adrenergic receptor agonist in the manufacture of medicaments for treating a disease involving orbital fat accumulation
Use of compositions comprising a beta-2 adrenergic receptor agonist in the manufacture of medicaments for treating a disease involving orbital fat accumulation
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机译:包含β-2肾上腺素能受体激动剂的组合物在制备用于治疗涉及眼眶脂肪蓄积的疾病的药物中的用途
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摘要
Compositions, formulations, methods, and systems for treating thyroid eye disease and related conditions (e.g., Grave's Ophthalmopathy). The methods described herein include administering, to a patient in need, systemic or local beta adrenergic agonists (e.g., as an extended release crystalline microparticle suspension). The methods can further include administering a compound for reducing beta adrenergic receptor desensitization (e.g., a corticosteroid) prior to administering or coadministered with the beta adrenergic agonist. The methods can also include locally administering to the eye an immunosuppressant agent (e.g., rapamycin) prior to administering a beta adrenergic agonist. The compositions described herein include ophthalmic pharmaceutical formulations of beta adrenergic agonists in the form of extended release crystalline microparticle suspensions or mixtures of the crystalline microparticle suspensions with beta adrenergic agonist solutions. The compositions also include ophthalmic formulations of a compound for reducing beta adrenergic receptor desensitization in the form of extended release crystalline microparticle suspensions.
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