Derivatives of piperidine with beta2 adrenergic receptor agonist activity and Muscarinic receptor antagonist, Pharmaceutical compositions containing Same, use thereof for the manufacture of medicaments for the treatment of pulmonary diseases, Methods for preparing these der

摘要

Claim 1: a compound of formula (1): wherein R1 is Methyl or Ethyl, R2 is Methyl or Ethyl, or a Salt or solvate or stereoisomer thereof acceptable for pharmaceutical use.Claim 21: an intermediate for preparing a compound of any of claims 1 to 4, wherein the Agent is a compound of formula (3): where Y1 is selected from Cho, - CN, - CH2OH (or3a) or3b, - ch, - C (o) Oh, - C (o) or3c, Bromine and iodine, where R3A and r3b is selec Each year, including Rent C1 - 6Or R3A and R2H are United to form a alquileno C2 - 6, R3C is selected from alkyl C1 - 6; r1 is Methyl or Ethyl, R2 is Methyl or Ethyl, or a Salt or stereoisomer of the same.Pharmaceutical compositions and combinations comprising such Compounds, processes and Intermediates for preparing such Compounds, and Methods of using Said Compound, for example, to treat pulmonary Disorders such as chronic obstructive pulmonary disease, and Asthma.