ANTI SNAKE VENOM PROPERTY OF RUTA GRAVEOLENS L. ON NAJA NAJA VENOM

摘要

Snake bite is one of the serious health hazards leading to high death rate in India. Cobra (Najanaja) is one of the most common snakes found in India. In the present study, the plant extracts of Ruta graveolens was tested against the snake venom. The plant extracts of benzene, diethyl ether, ethyl acetate, acetone and ethanol were used in which ethanol extract and acetone extract were effective. Thus the ethanol extract and acetone extract of Ruta graveolens were tested for antivenom activity against Najanaja venom by in vitro methods. The plant extracts were tested for procoagulation activity, phospholipase A2 activity, fibrinolytic activity and acetyl cholinesterase. It was found that the plant extracts were capable of inhibiting the snake venom. Thus the plant extracts is capable of neutralizing the venom toxicity and can be used for treatment in case of snake bite envenomation.