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ISOQUINOLINONE DERIVATIVES, COMPOSITIONS AND METHODS OF INHIBITING PHOSPHATIDYL INOSITOL-3 KINASE (PI3 KINASE)

机译:异喹啉酮衍生物,成分和抑制磷脂酰肌醇3激酶(PI3激酶)的方法

摘要

Disclosed herein is an isoquinolinone compound of formula I, wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful for inhibiting catalytic activity of phosphatidyl inositol-3 kinase (PI3 Kinase) present in a cell and also for treating disease manifesting an undesired immune response.
机译:本文公开了式I的异喹啉酮化合物,其中取代基如说明书中所定义,其制备方法,包含所述化合物的组合物及其用途。所述化合物可用于抑制细胞中存在的磷脂酰肌醇-3激酶(PI3激酶)的催化活性,还可用于治疗表现出不希望的免疫应答的疾病。

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