AMPHIPHILIC DRUG-OLIGOMER CONJUGATES WITH HYDROLYZABLE LIPOPHILE COMPONENTS AND METHODS FOR MAKING AND USING THE SAME

摘要

The present invention relates generally to hydrolyzable drug-oligomerconjugates, pharmaceutical compositions comprising such conjugates, and tomethods for making and using such conjugates and pharmaceutical compositions.For example, a conjugate of insulin, PEG, and oleic acid can be orallyadministered.