COMPOSITIONS AND METHODS FOR MODELING SACCHAROMYCES CEREVISIAE METABOLISM

摘要

The invention provides an in silica model for determining a S. cerevisiaephysiological function. The model includes a data structure relating aplurality of S. cerevisiae reactants to a plurality of S. cerevisiaereactions, a constraint set for the plurality of S. cerevisiae reactions, andcommands for determining a distribution of flux through the reactions that ispredictive ofa s. cerevisiae physiological function. A model of the inventioncan further include a gene database containing information characterizing theassociated gene or genes. The invention further provides methods for making anin silica S. cerevisiae model and methods for determining a S. cerevisiaephysiological function using a model of the invention.