Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof

摘要

#$%^&*AU2011201368B220130815.pdf#####P OPEku iMThe Res:rc, Founditno of Stitcl 922 Amndd PIVCS -It SPA -I .'N'4 ABSTRACT The present invention relates to novel methods for detection and isolation of cancer cells with metastatic potential from blood, ascites and tumor tissue derived from subjects with metastatic cancer. The invention further relates to novel compositions for use as celladhesion matrices for detection and isolation of cancer cells and for use as blood filters by subjects having metastatic cancers. The methods and compositions of the invention may also be used in assays designed for measuring the metastatic potential of isolated cancer cells and for identification of agents having anti-metastatic potential. In addition, the invention relates to inhibiting the metastatic potential of cancer cells by modulating the activity of serine integral membrane proteases expressed on the surface of metastasizing cancer cells.