CHIMERIC POLYPEPTIDES DERIVED FROM THE VIMENTIN PROTEIN, SUITABLE FOR USE IN THE DIAGNOSIS OF RHEUMATOID ARTHRITIS

摘要

The invention relates to chimeric polypeptides derived from the vimentin protein, which can detect the antibodies generated in rheumatoid arthritis (RA), comprising at least two citrullinated peptide subunits from: (i) a citrullinated peptide subunit from vimentin, (ii) a citrullinated peptide subunit from the α chain of fibrin and (iii) a citrullinated peptide subunit from filaggrin. In addition, the invention also relates to an antigenic composition, a method and kit for the diagnosis of rheumatoid arthritis based on the detection of the auto-antibodies generated over the course of the disease.