Exemplary systems and methods for generating information associated with at least one portion of a sample can be provided. For example, it is possible to receive from the at least one portion and/or transmit to at least one electro-magnetic radiation to the portion. At least one first wave front of the electro-magnetic radiation received from and/or transmitted to the portion can be provided to generate at least one first transmitted wave front. After the first transmitted wave front is generated, at least one characteristic of at least one second wave front of the electro-magnetic radiation received from and/or transmitted to the portion can be modified to generate at least one second modified wave front which is different from the first transmitted wave front;. Further, the information can be generated based on the first transmitted wave front and the second modified wave front.
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