首页> 外国专利> FISH-PROTEIN HYDROLYSATES USED IN PREVENTING AND/OR TREATING METABOLIC DISORDERS SUCH AS METABOLIC SYNDROME PARTICULARLY ASSOCIATED WITH OBESITY

FISH-PROTEIN HYDROLYSATES USED IN PREVENTING AND/OR TREATING METABOLIC DISORDERS SUCH AS METABOLIC SYNDROME PARTICULARLY ASSOCIATED WITH OBESITY

机译：鱼蛋白水解物，用于预防和/或治疗代谢紊乱，尤其是与肥胖相关的代谢综合征

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摘要

The present invention relates to fish-protein hydroysates used in preventing and/or treating metabolic disorders, such as metabolic syndrome particularly associated with obesity. According to the invention, the fish-protein hydrolysates are obtained by means of the enzymatic hydrolysis of at least one protein source selected from the group including the following fish: Micromesistius poutassou, Clupea harengus, Scomberscombrus, Sardina pilchardus,Trisopterus esmarki, Trachurus spp., Gadus morhua, Pollachius virens, Melanogrammus aeglefinus, Coryphaenoides rupestris, and fish belonging to order Siluriformes, wherein said enzymatic hydrolysis is carried out using an endopeptidase enzyme derived from Bacillus subtilis.

机译：本发明涉及用于预防和/或治疗代谢疾病，例如特别是与肥胖有关的代谢综合症的鱼蛋白水解物。根据本发明，通过至少一种选自以下鱼类的蛋白质来源的酶促水解获得鱼蛋白质水解物： Micromesistius poutassou ， Clupea harengus I>， Scomber scombrus ， Sardina pilchardus ， Trisopterus esmarki，Trachurus spp。，Gadus morhua，Pollachius virens，Melanogrammus aeglefinus ， Coryphaenoides rupestris 和属于Sil形目的鱼，其中所述酶促水解是使用衍生自枯草芽孢杆菌的内肽酶进行的。 展开▼

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公开/公告号WO2013034546A1

专利类型

公开/公告日2013-03-14

原文格式PDF

申请/专利权人 COMPAGNIE DES PECHES SAINT MALO SANTE;DUCLOS ELISA;
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申请/专利号WO2012EP67212

发明设计人 DUCLOS ELISA;
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申请日2012-09-04

分类号A23L1/327;A61K35/60;A61K38/01;A61P3;

国家 WO

入库时间 2022-08-21 16:34:28

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1. 含有印度醋栗提取物和大麦芽提取物的复合物(IB复合物)作为活性成分的用于预防、减轻或治疗伴有肥胖症和/或糖尿病的代谢综合征的组合物 [P] . 中国专利： CN114007631A . 2022-02-01

2. 用于预防或治疗肥胖或代谢综合征的新型化合物和包含其的药学组合物 [P] . 中国专利： CN112105598A . 2020-12-18

3. FISH-PROTEIN HYDROLYSATES USED IN PREVENTING AND/OR TREATING METABOLIC DISORDERS SUCH AS METABOLIC SYNDROME PARTICULARLY ASSOCIATED WITH OBESITY [P] . 欧洲知识产权局专利： EP2753194A1 . 2014-07-16

机译：鱼蛋白水解物，用于预防和/或治疗代谢紊乱，尤其是与肥胖相关的代谢综合征

4. Compound, pharmaceutical composition, methods to treat or prevent cardiovascular disease, dyslipidemia, dyslipoproteinemia, glucose metabolism disorder, thrombotic and associated with the peroxisome proliferator activated receptor, alzheimer's disease, syndrome x or metabolic syndrome , septicemia, obesity, pancreatitis, hypertension, kidney disease, cancer, inflammation and impotence, in a patient and to reduce the fat content of meat in farmed animals and cholesterol from poultry eggs [P] . BR0114617A . 2005-12-13

机译：化合物，药物组合物，治疗或预防心血管疾病，血脂异常，血脂蛋白异常，葡萄糖代谢异常，血栓形成以及与过氧化物酶体增殖物激活受体相关的药物，阿尔茨海默氏病，综合征x或代谢综合征，败血病，肥胖症，胰腺炎，高血压，肾脏疾病的方法，癌症，炎症和阳imp，以及减少家畜肉中的脂肪含量和禽蛋中的胆固醇

5. Compound, pharmaceutical composition, methods for treating or preventing cardiovascular disease, dyslipidemia, dyslipoproteinemia, glucose metabolism disorder, thrombotic and associated with peroxisome proliferator activated receptor, alzheimer's disease, x syndrome or metabolic syndrome , septicemia, obesity, pancreatitis, hypertension, kidney disease, cancer, inflammation and impotence, in a patient and to reduce the fat content of poultry eggs and poultry meat [P] . BR0114623A . 2005-12-13

机译：化合物，药物组合物，用于治疗或预防心血管疾病，血脂异常，血脂异常，葡萄糖代谢异常，血栓形成以及与过氧化物酶体增殖物激活受体相关的药物，阿尔茨海默氏病，x综合征或代谢综合征，败血病，肥胖症，胰腺炎，高血压，肾脏疾病，癌症，炎症和阳ot，降低患者禽蛋和禽肉的脂肪含量

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Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). 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