SYSTEMS AND INTEGRATED METHODS FOR GENE EXPRESSION ANALYSIS IN MULTIPLE SCLEROSIS

摘要

The present embodiments provide systems and methods for determining gene signatures relating to MS and specifically interferon-based treatments including gene/differential gene expression database for providing a gene predictor set; a biology grouping system downstream from the gene data system for providing statistical grouping of genes for association with common biologies; and a disease grouping system downstream from the biology grouping system for analytically grouping genes for association with a particular disease and determining gene signatures. Methods for drug and biomarker discovery include providing a gene predictor set; selecting a portion of genes from the gene predictor set and statistically grouping the genes according to effect on biological function to define a biological function gene set; selecting genes from the biological function gene set and analytically grouping them to define gene signatures.