METHOD FOR CLASSIFYING NON-MICROCYTIC LUNG CARCINOMA ON THE BASIS OF IDENTIFYING AN INTRATUMORAL IMMUNE RESPONSE

摘要

The present invention relates to an in vitro method for classifying non-microcytic lung carcinoma on the basis of the differential expression of 50 genes. Said genes identify an intratumoral immune response. The method of the invention is used to differentiate patients with an expression profile of genes associated with an immune response which is associated with a good prognosis and patients without said expression profile, who have worse prognosis. Said classification can be used as a prognostic marker, as a tumour classifier in accordance with the intratumoral immune response (immunoscore) or as a biomarker predicting therapies based on the immune system (immunotherapy). The present invention also relates to a kit which includes a set of probes that recognise the 50 genes of the invention.