Classification method for non-small cell lung carcinoma based on the identification of an intratumoral immune response.

摘要

Classification method for non-small cell lung carcinoma based on the identification of an intratumoral immune response. The present invention relates to an in vitro method of classification of non-small cell lung carcinoma based on the differential expression of 50 genes. These genes identify an intratumoral immune response. By the method of the invention, patients with an expression profile of genes associated with an immune response that is associated with a good prognosis are distinguished and patients without that expression profile have a worse prognosis. This classification can be used as a prognostic marker, as a tumor classifier based on the antitumor immune response ("immunoscore") or as a biomarker predictor of immune system-based therapies (immunotherapy). The present invention also relates to a kit comprising a set of probes that recognize the 50 genes of the invention.