PURPOSE: A fermentation method of a Citrus junos and cassia seeds mixture is provided to be useful and effective to human body by fermenting Citrus junos and cassia seeds in the optimal condition. CONSTITUTION: A fermentation method of a Citrus junos and cassia seeds mixture comprises the following steps: a cutting step(S10) of cutting Citrus junos peel and fruit into a certain size, and removing seeds; a pulverizing step(S20) of cutting washed and dried cassia seeds, and making powder; a stirring step(S30) of mixing the Citrus jonos peels and fruit pieces and the cassia seeds in a ratio of 1:0.15-0.20; and a first fermentation composition manufacturing step of placing the mixture into a container, and fermenting at 4-10 deg. C for 24-26 hours. A second fermentation composition is manufactured by fermenting 100 parts by weight of first fermentation composition and 20 parts by weight cassia seeds extract at 5-20 deg. C for 25-35 days. [Reference numerals] (A1) Cutting step; (A2) Separating the peel and fruit of citrus junos and cutting into a certain size; (A3) Peel and fruit pieces produced; (B1) Pulverizing step; (B2) Pulverizing cassia seeds; (B3) Cassia seed powder; (C1) Stirring step; (C2) Peel pieces + Fruit pieces + Cassia seed powder; (C3) Mixture; (D1) First fermentation step; (D2) Mixture; (D3) 24-26 hours; (D4) First fermentation composition; (E1) Second fermentation step; (E2) First fermentation composition + Cassia seed extract; (E3) 25-35 days; (E4) Second fermentation composition; (F1) Third fermentation step; (F2) Second fermentation composition + Cassia seed extract; (F3) 30-45 days; (F4) Third fermentation composition;
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