PURPOSE: A method for purifying sesaminol glycoside and a use of sesaminol glycoside are provided to obtain sesaminol glycoside by supercritical extraction of sesame at 450 bar and 65 deg. C. CONSTITUTION: A method for purifying sesaminol glycoside comprises a step of extracting sesame at 450 bar and 65 deg. C. A pharmaceutical composition for preventing or treating Alzheimer's disease contains sesaminol glycoside as an active ingredient. A composition for health functional foods contains sesaminol glycoside as an active ingredient. [Reference numerals] (AA) Sesame; (BB) Sesame oil; (CC) Defatted sesame powder; (DD) Water extraction(100C, 1 hour); (EE) Sesame water extract; (FF) Defatted sesame powder, Water extracted residue; (GG) Sesaminol glycoside; (HH) Enzyme treatment
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