PHARMACEUTICAL COMPOSITION COMPRISING (Z)-N-(3-(2,4-DIFLUOROPHENYLAMINO)-1-(4-NITROPHENYL)-3-OXOPROP-1-EN-2-YL)-2-METHOXYBENZAMIDE FOR PREVENTING AND TREATING OF NEURODEGENERATIVE DISEASE

摘要

PURPOSE: A pharmaceutical composition containing (Z)-N-(3-(2,4-difluorophenylamino)-1-(4-nitrophenyl)-3-oxoprop-1-en-2-yl)-2-methoxybenzamide for preventing and treating neurodegenerative diseases is provided to suppress A beta decomposition and to prevent and treat Alzheimer' disease. CONSTITUTION: A pharmaceutical composition for preventing and treating Alzheimer's disease, Parkinson' disease, amylotrophic lateral scelerosis(ALS), or dementia contains (Z)-N-(3-(2,4-difluorophenylamino)-1-(4-nitrophenyl)-3-oxoprop-1-en-2-yl)-2-methoxybenzamide or a pharmaceutically acceptable salt thereof as an active ingredient. The compound of chemical formula 1 specifically suppresses a SI pocket of GCP II(Glutamate Carboxypeptidase II) and strengthens synapse at an early stage. The compound of chemical formula 1 maintains homeostasis of intracellular amyloid beta(A beta).