Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome

摘要

The present invention relates to methods useful for treating one or more subtypes of irritable bowel syndrome (IBS) or diarrhea. The present invention relates to a peripheral selective kappa-opiate agonist for treating a subject having diarrhea-predominant irritable bowel syndrome (IBS-D) or irritable bowel syndrome (IBS-A) with alternating diarrhea or constipation , In particular N-methyl-N-[(1S) -1-phenyl-2-((3S) -3-hydroxypyrrolidin-1-yl) ethyl] -2,2-diphenylacetamide and / or It relates to the use of pharmaceutically acceptable salts thereof.