KAPPA-OPIATE AGONIST FOR TREATMENT OF DIARRHEA-PREDOMINANT AND ALTERNATING IRRITABLE BOWEL SYNDROME

摘要

PROBLEM TO BE SOLVED: To provide methods useful in treating one or more subtypes of irritable bowel syndrome (IBS), or useful in treating diarrhea.SOLUTION: The invention relates to the use of peripherally selective kappa-opiate agonists, especially N-methyl-N-[(1S)-1-phenyl-2-((3S)-3-hydroxypyrrolidin-1-yl)ethyl]-2,2-diphenylacetamide and/or a pharmaceutically acceptable salt thereof for treating a subject having diarrhea-predominant IBS (IBS-D) or IBS (IBS-A) with alternating diarrhea and constipation, or a subject having diarrhea.