MODULATORS OF MELANOCORTIN RECEPTORS, METHOD FOR THEIR PRODUCTION AND THEIR APPLICATION IN MEDICINES AND COSMETIC DRUGS FOR HUMAN

摘要

1. The compound of General formula (I) where R1 represents a hydrogen atom, aryl, substituted aryl, alkyl, cycloalkyl, cycloalkylalkyl or cycloalkylalkylalkyl, R2 represents a hydrogen atom, hydroxyl, lower alkyl, substituted lower alkyl, higher alkyl, substituted higher alkyl, cycloalkyl, cycloalkylalkyl, lower alkoxy, substituted lower alkoxy, higher alkoxy, substituted higher alkoxy, cycloalkylalkoxy, acyloxy, acyl, alkoxycarbonyl, carboxamide, carboxylic acid, cyano or amino, disubstituted with acyl and aryl pre-alkyl, R is aralkyl or substituted aralkyl, R4 is heteroaralkyl or substituted heteroaralkyl, R5 is a hydrogen atom or alkyl, X is an oxygen atom or a sulfur atom, n, m are 1 or 2; as well as the corresponding salts and enantiomers. 2. The compound of general formula (I) according to claim 1, wherein: R1 represents a hydrogen atom, aryl, substituted aryl, alkyl, cycloalkyl or cycloalkylalkyl, R2 represents a hydrogen atom, lower alkyl, substituted lower alkyl, higher alkyl, substituted higher alkyl, cycloalkyl, cycloalkylalkyl, lower alkoxy, substituted lower alkoxy, higher alkoxy, substituted higher alkoxy, cycloalkylalkoxy, acyloxy, acyl, alkoxycarbonyl, carboxamide or cyano, R3 is aralkyl or substituted aralkyl, R4 is heteroalkyl eroaralkil, R5 represents a hydrogen atom, X represents an oxygen atom or a sulfur atom, n, m are 1 or 2; and corresponding salts and enantiomery.3. The compound of general formula (I) according to claim 2, wherein: R1 is cycloalkyl or cycloalkylalkyl, R2 is lower alk