MELANOCORTIN RECEPTOR MODULATOR, METHOD FOR PREPARING MELANOCORTIN RECEPTOR MODULATOR, AND USE THEREOF IN HUMAN MEDICINE AND COSMETIC

摘要

PROBLEM TO BE SOLVED: To provide a compound having activity of modulating melanocortin receptors, and a pharmaceutical composition and a cosmetic composition comprising the compound.SOLUTION: The present invention provides a compound represented by following formula, and a pharmaceutical composition and a cosmetic composition comprising the compound. In the formula, R1 represents a hydrogen atom, an aryl, an alkyl, a cycloalkyl or the like; R2 represents a hydrogen atom, a hydroxyl, an alkyl, a cycloalkyl, an alkoxy, a cycloalkylalkoxy, an acyloxy, an acyl, an alkoxycarbonyl, a carboxamide, a carboxyl, a cyano or the like; R3 represents an aralkyl or a substituted aralkyl; R4 represents a heteroaralkyl or a substituted heteroaralkyl; R5 represents a hydrogen atom or an alkyl; X represents an oxygen atom or a sulfur atom; and n and m each represent 1 or 2.