MEDICAMENT, FUNCTIONAL FOOD PRODUCT, STABILIZATION METHOD OF TARGET PROTEIN, FUSION PROTEIN, NUCLEIC ACID, AND RECOMBINANT

摘要

PROBLEM TO BE SOLVED: To provide a series of techniques by specifying a new protein carrier for a therapeutic peptide and using the carrier.SOLUTION: A medicament contains a fusion protein where apolipoprotein AI or a modified body thereof and a therapeutic peptide as an active ingredient are linked through a peptide bond. The medicament has a long half-life in blood and low possibility of antibody production, and allows oral administration and transmucosal administration. The modified body may be a partial fragment of apolipoprotein AI, a polypeptide comprising 1 to 6 amphiphatic sequences, an amino acid variant, a mimic peptide or the like. Examples of the therapeutic peptide include a glucagon-like peptide-1 (GLP-1). A medicament with a lipid being further bonded to the fusion protein to form a protein/lipid complex is also provided.