Of 1- (4- (4- (3,4-dichloro-2-fluorophenylamino) -7-methoxyquinazolin-6-yloxy) piperidin-1-yl) -prop-2-en-1-one hydrochloride Production method and intermediate used in the method

摘要

The present invention selectively and effectively inhibits the growth of cancer cells induced by overexpression of epidermal growth factor receptor (EGFR) and prevents the development of drug resistance caused by mutations in tyrosine kinases. Preparation of (4- (4- (3,4-dichloro-2-fluorophenylamino) -7-methoxyquinazolin-6-yloxy) piperidin-1-yl) -prop-2-en-1-one hydrochloride And an intermediate used in the method.