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Multiple dye-doped silica nanoparticles featuring highly efficient energy transfer and tunable stalk shift
Multiple dye-doped silica nanoparticles featuring highly efficient energy transfer and tunable stalk shift
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机译:多种染料掺杂的二氧化硅纳米粒子,具有高效的能量转移和可调节的茎偏移
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摘要
The present invention relates to silica nanoparticles comprising at least two dyes. Said dyes have a respective relationship of donor-acceptor couple in an energy transfer process and have a molar absorption coefficient ≧10,000 M−1 cm−1 for the considered spectral region, a fluorescence quantum yield ≧0.01, good overlap integral, according to the Förster theory, between said donor and said acceptor dye; said active compounds may be lipophilic or may present a functionality useful for the introduction of a trialkoxysilane moiety. The dyes provide an efficient energy transfer process. Said nanoparticles are useful as probes in the field of medicine, in particular therapy and diagnostics, more particularly in theranostics, and in the field of analytical chemistry.
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