SiRNA that inhibits expression of Hif1α and anticancer composition containing the same

摘要

Disclosed are small interfering RNA (siRNA) that complementarily binds to a base sequence of Hif1alpha mRNA transcript, thereby inhibiting expression of Hif1alpha without inducing immune responses, and a use of the siRNA for prevention and/or treatment of cancer. Since Hif1alpha is commonly overexpressed in almost all cancer cells, the siRNA that complementarily binds to Hif1alpha-encoding mRNA may inhibit expression of Hif1alpha through RNA-mediated interference (RNAi), thereby inhibiting proliferation and metastasis of cancer cells, and thus, the siRNA may be useful as an anticancer agent.