SIRNA FOR INHIBITION OF HIF1 EXPRESSION AND ANTICANCER COMPOSITION CONTAINING THE SAME

摘要

PURPOSE: An anticancer composition using siRNA is provided to suppress Hif1alpha expression and to suppress cancer cell proliferation and metastasis. CONSTITUTION: A double strand siRNA of 15-30 bp targets mRNA corresponding to one selected from bases of sequence numbers 2, 3, and 5-14. The siRNA also targets mRNA corresponding to a base of sequence number 6, 10, or 12. The siRNA has a nucleotide sequence of siRNA 1, siRNA 2, siRNA 4-siRNA 13, or siRNA 18-siRNA 20. An expression vector contains the siRNA. The expression vector is a plasmid, adeno-associated virus vector, retrovirus vector, vaccinia virus vector, or oncolytic adenovirus vector. An anticancer composition contains the siRNA in a complex form together with a nucleic acid delivery system.