Of primary aldosteronism adenomas and differentiation method 18-oxo-cortisol (18-oxoF), measurement method 18-hydroxy-cortisol (18-OHF)

摘要

The present invention provides an adenoma discrimination method using a 18-oxoF present in the peripheral blood of primary aldosteronism patients. In addition, there is provided a compound and measuring method according to LC-MS of, 18-OHF 18-oxoF in the sample. More particularly, after alkoxylation the sample 18-oxoF, or directly, the method and the ester derivative by reacting a compound represented by the 18-OHF following formula (I), measuring the ester derivative obtained I provide the ester derivative. (In the formula, R1 is a hydrogen atom, a halogen atom, C _1-4 alkyl, C _1-4 alkoxy group, an allyl C _1-4 alkoxy, C _1-4 alkylamino group, a di (C _1-4 alkyl) represents an amino group, a cyano group or a nitro group, X is. representing a leaving group or a hydroxyl group)