The proline amide derivative, that and production manner of the hydroxy carbonyl compound which uses the organicity catalytic converter and its organicity catalytic converter which are formed with the salt of the Acid

摘要

Provided is a novel organic catalyst for an aldol reaction which achieves a higher stereoselectivity of a reaction product than the existing catalysts. Also provided is a method of producing a -hydroxycarbonyl compound using this novel organic catalyst. A -hydroxycarbonyl compound is produced by an aldol reaction with the use of a prolineamide derivative having a structure represented by formula (i) or an enantiomer of the structure represented by formula (i) or a salt thereof together with an acid as a catalyst in the aldol reaction: (i) (in the formula and R represents a heteroaryl group optionally having a substituent).