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Proline amide derivatives, process for producing the same β- hydroxy carbonyl compounds using salts with acids, and organic catalysts and organic catalysts that consists of those
Proline amide derivatives, process for producing the same β- hydroxy carbonyl compounds using salts with acids, and organic catalysts and organic catalysts that consists of those
[Challenge] I will provide a novel organic catalysts of aldol reaction stereoselectivity of the reaction product is higher than the conventional catalysts. Also, there is provided a method of manufacturing β- hydroxy carbonyl compounds using the new organic catalysts. [MEANS FOR SOLVING PROBLEMS] [Formula 1] (R in the formula represents an optionally substituted heteroaryl group which may have a substituent) Structure, or formula (I), or proline amide derivatives, are enantiomers of the structure of formula (I), same can be used as catalysts for aldol reaction to salts with acids by aldol reaction β- I to produce the hydroxy carbonyl compounds. None [Selection Figure]
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