IMMUNOMODULATION BY CONTROLLING INTERFERON-GAMMA LEVELS WITH THE LONG NON-CODING RNA NeST

摘要

Compositions and methods of modulating an immune response by controlling levels of interferon-gamma (IFN-γ) production by leukocytes are disclosed. Adjustment of IFN-γ levels is achieved by increasing or decreasing the activity of NeST (nettoie Salmonella pas Theiler's [cleanup Salmonella not Theiler's]), a long non-coding RNA that induces expression of IFN-γ. In particular, the invention relates to the use of NeST and inhibitors of NeST to modulate levels of IFN-γ for treatment of inflammatory conditions, autoimmune diseases, infectious diseases, immunodeficiency, and cancer.