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Monoclonal antibody and its use for the identification of the oncofetal isoform of fibronectin (B-FN) for diagnosis or therapy

机译：单克隆抗体及其在识别纤连蛋白的胎粪同工型（B-FN）中的用途，以进行诊断或治疗

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摘要

Epitopes localized on FNIII-8 repeat that are normally cryptic but are unmasked by insertion of FNIII-B into the FN molecule and are recognized by specific ligands are described; antibodies or their fragments able to identify the above said epitope are also described.

机译：描述了位于FNIII- 8 重复序列上的抗原决定簇，这些抗原决定簇通常是隐秘的，但无法通过将FNIII-B插入FN分子而被掩盖并被特定的配体识别。还描述了能够识别上述表位的抗体或其片段。 展开▼

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公开/公告号US8728740B2

专利类型

公开/公告日2014-05-20

原文格式PDF

申请/专利权人 PATRIZIA CASTELLANI;FRANCESCA SASSI;M. BARBARA CARNEMOLLA;LAURA BORSI;ENRICA BALZA;
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申请/专利号US200913139112

发明设计人 PATRIZIA CASTELLANI;FRANCESCA SASSI;M. BARBARA CARNEMOLLA;LAURA BORSI;ENRICA BALZA;
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申请日2009-12-11

分类号G01N33/53;

国家 US

入库时间 2022-08-21 16:04:11

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